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. ۵۰x, so as to make it clear in the first place. 7 and 8 computers, as far as your bios goes, has to do with the drive.Bone marrow transplantation (BMT) can cure many, but not all, patients with various hematologic disorders. Autologous or syngeneic allogeneic transplants are able to provide many of these cures. However, such transplants produce graft-versus-host disease (GVHD), an incurable disorder of the immune system. As a result, researchers have attempted to produce allogeneic, or non-self, blood or bone marrow transplants. Allografts cure many, but not all, patients with various hematologic malignancies or genetic disorders. Chronic myelogenous leukemia (CML), an incurable disorder of the hematopoietic system, is frequently treated with allogenic bone marrow transplants (Alupe et al., Blood. 70:3610-8 (1987)).
CML is a myeloproliferative disorder in which the symptoms reflect both an abnormal excess of normal hematopoietic elements and a relative deficiency in the hematopoietic elements necessary for combating infection. The etiology of CML is unknown. CML may result from a somatic mutation, i.e., a mutation occurring in a single cell that is not inherited.
The disease is characterized by the presence of a single, uncontrolled population of myeloid (white blood cell) stem cells, called “Philadelphia chromosome (Ph)-positive” cells in the bone marrow and peripheral blood. The hematopoietic system is disabled as a consequence of overproduction of circulating leukocytes, and the hematopoietic tissue becomes deformed, enlarged and prone to infection. In extreme cases, the Ph-positive stem cells accumulate and ultimately replace the entire bone marrow. Ultimately, these hematopoietic stem cells produce mature myeloid cells, causing the body to lack the ability to fight infection.
The disease is usually diagnosed through clinical hematologic and cytogenetic analysis and/or fluorescence in situ hybridization (FISH) analysis. For example, the presence of the